| Points | Club | VS Club | Date | |
|---|---|---|---|---|
| 71 | Saracens | Bath | 17-10-2021 | Match details |
| 66 | Northampton Saints | Worcester Warriors | 22-10-2021 | Match details |
| 55 | Leicester Tigers | Northampton Saints | 30-10-2021 | Match details |
| 52 | Harlequins | Bristol Bears | 08-10-2021 | Match details |
| 45 | Bristol Bears | London Irish | 30-10-2021 | Match details |
| 42 | Exeter Chiefs | Worcester Warriors | 09-10-2021 | Match details |
| 36 | Worcester Warriors | London Irish | 18-09-2021 | Match details |
| 34 | London Irish | Saracens | 06-11-2021 | Match details |
| 33 | Gloucester | Sale Sharks | 09-10-2021 | Match details |
| 32 | Sale Sharks | Gloucester | 09-10-2021 | Match details |
| 27 | London Wasps | Bath | 30-10-2021 | Match details |
| 23 | Newcastle Falcons | Saracens | 09-10-2021 | Match details |
| 23 | Bath | Leicester Tigers | 05-11-2021 | Match details |
