| Penalties | Club | VS Club | Date | |
|---|---|---|---|---|
| 7 | Saracens | Bristol Bears | 17-09-2021 | Match details |
| 5 | Gloucester | Newcastle Falcons | 23-10-2021 | Match details |
| 4 | Bristol Bears | Leicester Tigers | 26-12-2021 | Match details |
| 4 | Northampton Saints | Bristol Bears | 26-11-2021 | Match details |
| 4 | Leicester Tigers | Bath | 05-11-2021 | Match details |
| 4 | Bath | Sale Sharks | 18-09-2021 | Match details |
| 4 | London Wasps | London Irish | 26-12-2021 | Match details |
| 4 | Sale Sharks | Saracens | 01-04-2022 | Match details |
| 3 | Worcester Warriors | Gloucester | 02-10-2021 | Match details |
| 3 | London Irish | Leicester Tigers | 09-10-2021 | Match details |
| 3 | Harlequins | Leicester Tigers | 23-04-2022 | Match details |
| 3 | Newcastle Falcons | Saracens | 09-10-2021 | Match details |
| 3 | Exeter Chiefs | Bath | 26-11-2021 | Match details |
