| MD | Players | Nationality | DOB | A(D) |
|---|---|---|---|---|
| 07-Aug-2021 | Alan Wyn Jones | Wales | 19-Sep-1985 | 35(323) |
| 07-Aug-2021 | Ken Owens | Wales | 03-Jan-1987 | 34(217) |
| 07-Aug-2021 | Courtney Lawes | England | 23-Feb-1989 | 32(165) |
| 31-Jul-2021 | Conor Murray | Ireland | 20-Apr-1989 | 32(102) |
| 26-Jun-2021 | Justin Tipuric | Wales | 06-Aug-1989 | 31(324) |
| 07-Aug-2021 | Daniel Biggar | Wales | 16-Oct-1989 | 31(295) |
| 07-Aug-2021 | Bundee Aki | Ireland | 07-Apr-1990 | 31(123) |
| 31-Jul-2021 | Chris Harris | Scotland | 28-Dec-1990 | 30(216) |
| 31-Jul-2021 | Makovina Vunipola | England | 13-Jan-1991 | 30(200) |
| 07-Aug-2021 | Liam Williams | Wales | 09-Apr-1991 | 30(121) |
| 07-Aug-2021 | Wyn Jones | Wales | 26-Feb-1992 | 29(163) |
| 26-Jun-2021 | Iain Henderson | Ireland | 21-Feb-1992 | 29(126) |
| 31-Jul-2021 | Stuart Hogg | Scotland | 24-Jun-1992 | 29(37) |
| 07-Aug-2021 | Jack Conan | Ireland | 29-Jul-1992 | 29(9) |
| 24-Jul-2021 | Rory Sutherland | Scotland | 24-Aug-1992 | 28(334) |
| 26-Jun-2021 | Tadhg Beirne | Ireland | 01-Aug-1992 | 28(329) |
| 24-Jul-2021 | Elliot Daly | England | 08-Oct-1992 | 28(289) |
| 07-Aug-2021 | Tadhg Furlong | Ireland | 14-Nov-1992 | 28(266) |
| 07-Aug-2021 | Ali Price | Scotland | 12-May-1993 | 28(87) |
| 07-Aug-2021 | Robbie Henshaw | Ireland | 12-Jun-1993 | 28(56) |
| 31-Jul-2021 | Luke Cowan-Dickie | England | 20-Jun-1993 | 28(41) |
| 31-Jul-2021 | Anthony Watson | England | 26-Feb-1994 | 27(155) |
| 07-Aug-2021 | Maro Itoje | England | 28-Oct-1994 | 26(284) |
| 07-Aug-2021 | Josh Adams | Wales | 21-Apr-1995 | 26(109) |
| 07-Aug-2021 | Duhan van der Merwe | Scotland | 04-Jun-1995 | 26(65) |
| 07-Aug-2021 | Tom Curry | England | 15-Jun-1998 | 23(53) |
MD = Match date,
DOB = Date of birth,
A(D) = Age(days).