| Points | Players | VS Club | Date | |
|---|---|---|---|---|
| 23 | Benoit Paillaugue | Benetton Treviso | 10-04-2021 | Match details |
| 16 | Alex Lozowski | Glasgow Warriors | 02-04-2021 | Match details |
| 11 | Benoit Paillaugue | Bath | 01-05-2021 | Match details |
| 8 | Benoit Paillaugue | Leicester Tigers | 21-05-2021 | Match details |
| 5 | Guilhem Guirado | Glasgow Warriors | 02-04-2021 | Match details |
| 5 | Anthony Bouthier | Glasgow Warriors | 02-04-2021 | Match details |
| 5 | Paul Willemse | Benetton Treviso | 10-04-2021 | Match details |
| 5 | Yacouba Camara | Bath | 01-05-2021 | Match details |
| 5 | Vincent Rattez | Leicester Tigers | 21-05-2021 | Match details |
| 5 | Johan Goosen | Leicester Tigers | 21-05-2021 | Match details |
| 3 | Anthony Bouthier | Benetton Treviso | 10-04-2021 | Match details |
| 3 | Handre Pollard | Bath | 01-05-2021 | Match details |
