| MD | Players | Club | Nationality | DOB | A(D) |
|---|---|---|---|---|---|
| 19-Nov-2021 |  Georgie Irvine | Northampton Saints | England | 05-Aug-2003 | 18(107) |
| 20-Nov-2021 |  Reiketi Ma'asi-White | London Wasps | England | 03-Feb-2003 | 18(291) |
| 20-Nov-2021 |  Dafydd Jenkins | Exeter Chiefs | Wales | 05-Dec-2002 | 18(351) |
| 19-Nov-2021 |  Henry Arundell | London Irish | England | 08-Nov-2002 | 19(11) |
| 19-Nov-2021 | George Hendy | Northampton Saints | England | 15-Oct-2002 | 19(35) |
| 19-Nov-2021 |  Jamie Benson | Harlequins | England | 23-Sep-2002 | 19(57) |
| 20-Nov-2021 | Ollie Burrows | Exeter Chiefs | Wales | 16-May-2002 | 19(188) |
| 19-Nov-2021 | Tom Litchfield | Northampton Saints | England | 20-Apr-2002 | 19(213) |
| 20-Nov-2021 | Ollie Hartley | London Wasps | England | 19-Feb-2002 | 19(274) |
| 19-Nov-2021 |  Toby Knight | Saracens | England | 05-Jan-2002 | 19(318) |
| 20-Nov-2021 |  Louis Hillman-Cooper | Gloucester | England | 22-Dec-2001 | 19(333) |
| 20-Nov-2021 | Arthur Clark | Gloucester | England | 19-Dec-2001 | 19(336) |
| 20-Nov-2021 | Freddie Thomas | Gloucester | England | 09-Nov-2001 | 20(11) |
| 20-Nov-2021 | Dan John | Exeter Chiefs | Wales | 04-Oct-2001 | 20(47) |
| 19-Nov-2021 | Brandon Jackson | Saracens | England | 21-Sep-2001 | 20(59) |
| 19-Nov-2021 |  Elliot Gourlay | Sale Sharks | Scotland | 12-Sep-2001 | 20(68) |
| 20-Nov-2021 | Harry Taylor | Gloucester | England | 09-Sep-2001 | 20(72) |
| 20-Nov-2021 | James Tunney | London Wasps | England | 14-Jul-2001 | 20(129) |
| 20-Nov-2021 |  George Martin | Leicester Tigers | England | 18-Jun-2001 | 20(155) |
| 20-Nov-2021 | Daniel Kelly | Leicester Tigers | England | 16-Jun-2001 | 20(157) |
| 20-Nov-2021 | Arthur Relton | Exeter Chiefs | England | 07-Jun-2001 | 20(166) |
| 20-Nov-2021 |  Jack Bates | Bristol Bears | England | 26-May-2001 | 20(178) |
| 20-Nov-2021 | Daniel Lancaster | Leicester Tigers | England | 23-May-2001 | 20(181) |
| 20-Nov-2021 | Jack van Poortvliet | Leicester Tigers | England | 15-May-2001 | 20(189) |
| 20-Nov-2021 | Ioan Lloyd | Bristol Bears | Wales | 05-Apr-2001 | 20(229) |
| 20-Nov-2021 | Jack Clement | Gloucester | England | 27-Feb-2001 | 20(266) |
| 20-Nov-2021 | Tommy Mathews | London Wasps | England | 05-Feb-2001 | 20(288) |
| 20-Nov-2021 | Mario Pichardie | London Wasps | Spain | 31-Jan-2001 | 20(293) |
| 19-Nov-2021 | Tom Roebuck | Sale Sharks | England | 07-Jan-2001 | 20(316) |
| 19-Nov-2021 | Theodor Dan | Saracens | England | 26-Dec-2000 | 20(328) |
| 19-Nov-2021 | Ollie Newman | Northampton Saints | England | 01-Dec-2000 | 20(353) |
| 19-Nov-2021 | Lennox Anyanwu | Harlequins | England | 29-Nov-2000 | 20(355) |
| 19-Nov-2021 | Emmanuel Iyogun | Northampton Saints | England | 24-Nov-2000 | 20(360) |
| 20-Nov-2021 | James Whitcombe | Leicester Tigers | England | 20-Nov-2000 | 20(365) |
| 20-Nov-2021 | George Barton | Gloucester | England | 07-Nov-2000 | 21(13) |
| 19-Nov-2021 |  Will Haydon-Wood | Newcastle Falcons | England | 27-Oct-2000 | 21(23) |
| 19-Nov-2021 | Joshua Gillespie | Northampton Saints | England | 20-Oct-2000 | 21(30) |
| 20-Nov-2021 | Oliver Chessum | Leicester Tigers | England | 06-Sep-2000 | 21(75) |
| 19-Nov-2021 | Chunya Munga | London Irish | England | 02-Sep-2000 | 21(78) |
| 20-Nov-2021 |  Harri Doel | Worcester Warriors | Wales | 02-Aug-2000 | 21(110) |
| 19-Nov-2021 | George Hammond | Harlequins | England | 31-Jul-2000 | 21(111) |
| 20-Nov-2021 | Josh Hodge | Exeter Chiefs | England | 23-May-2000 | 21(181) |
| 20-Nov-2021 | Rusi Tuima | Exeter Chiefs | England | 21-May-2000 | 21(183) |
| 20-Nov-2021 | Jacob Morris | Gloucester | England | 12-May-2000 | 21(192) |
| 19-Nov-2021 | Manu Vunipola | Saracens | England | 04-May-2000 | 21(199) |
| 19-Nov-2021 | Hugh Tizard | Harlequins | England | 31-Mar-2000 | 21(233) |
| 20-Nov-2021 | Sam Maunder | Exeter Chiefs | England | 22-Mar-2000 | 21(243) |
| 19-Nov-2021 | Robert Farrar | Newcastle Falcons | England | 16-Mar-2000 | 21(248) |
| 19-Nov-2021 | Jack Musk | Harlequins | England | 04-Mar-2000 | 21(260) |
| 20-Nov-2021 | Richard Capstick | Exeter Chiefs | England | 13-Feb-2000 | 21(281) |
MD = Match date,
DOB = Date of birth,
A(D) = Age(days).