| Points | Players | VS Club | Date | |
|---|---|---|---|---|
| 11 | Jack Crowley | Castres | 14-01-2022 | Match details |
| 11 | Ben Healy | London Wasps | 23-01-2022 | Match details |
| 10 | Simon Zebo | London Wasps | 23-01-2022 | Match details |
| 9 | Joey Carbery | Toulouse | 07-05-2022 | Match details |
| 5 | Gavin Coombes | Castres | 14-01-2022 | Match details |
| 5 | Conor Murray | London Wasps | 23-01-2022 | Match details |
| 5 | Jack O'Donoghue | London Wasps | 23-01-2022 | Match details |
| 5 | Jeremy Loughman | London Wasps | 23-01-2022 | Match details |
| 5 | Rory Scannell | London Wasps | 23-01-2022 | Match details |
| 5 | Shane Daly | Exeter Chiefs | 09-04-2022 | Match details |
| 5 | Alex Kendellen | Toulouse | 07-05-2022 | Match details |
| 5 | Keith Earls | Toulouse | 07-05-2022 | Match details |
| 5 | Michael Haley | Toulouse | 07-05-2022 | Match details |
| 4 | Jack Crowley | London Wasps | 23-01-2022 | Match details |
| 3 | Ben Healy | Exeter Chiefs | 09-04-2022 | Match details |
