| Points | Players | VS Club | Date | |
|---|---|---|---|---|
| 16 | Marcus Smith | Cardiff Blues | 14-01-2022 | Match details |
| 15 | Alex Dombrandt | Castres | 21-01-2022 | Match details |
| 9 | Tommaso Allan | Castres | 21-01-2022 | Match details |
| 6 | Marcus Smith | Montpellier | 10-04-2022 | Match details |
| 5 | Louis Lynagh | Cardiff Blues | 14-01-2022 | Match details |
| 5 | Tyrone Green | Cardiff Blues | 14-01-2022 | Match details |
| 5 | Luke Northmore | Cardiff Blues | 14-01-2022 | Match details |
| 5 | Danny Care | Cardiff Blues | 14-01-2022 | Match details |
| 5 | Huw Jones | Castres | 21-01-2022 | Match details |
| 5 | Villiami Taulani | Castres | 21-01-2022 | Match details |
| 5 | George Hammond | Montpellier | 10-04-2022 | Match details |
| 5 | Andre Esterhuizen | Montpellier | 10-04-2022 | Match details |
| 5 | Joe Marchant | Montpellier | 10-04-2022 | Match details |
| 5 | Louis Lynagh | Montpellier | 10-04-2022 | Match details |
| 2 | Marcus Smith | Castres | 21-01-2022 | Match details |
