| Points | Players | VS Club | Date | |
|---|---|---|---|---|
| 15 | Callum Sheedy | Scarlets | 22-01-2022 | Match details |
| 10 | Piers O'Conor | Stade Francais | 15-01-2022 | Match details |
| 10 | Semi Radradra | Scarlets | 22-01-2022 | Match details |
| 8 | Callum Sheedy | Stade Francais | 15-01-2022 | Match details |
| 5 | Henry Purdy | Stade Francais | 15-01-2022 | Match details |
| 5 | Harry Randall | Stade Francais | 15-01-2022 | Match details |
| 5 | Ioan Lloyd | Scarlets | 22-01-2022 | Match details |
| 5 | Harry Thacker | Scarlets | 22-01-2022 | Match details |
| 5 | Piers O'Conor | Scarlets | 22-01-2022 | Match details |
| 5 | Ratu Naulago | Scarlets | 22-01-2022 | Match details |
| 5 | Callum Sheedy | Sale Sharks | 09-04-2022 | Match details |
| 5 | Semi Radradra | Sale Sharks | 09-04-2022 | Match details |
