| Points | Players | VS Club | Date | |
|---|---|---|---|---|
| 24 | JJ Hanrahan | Clermont Auvergne | 19-12-2020 | Match details |
| 10 | Keith Earls | Toulouse | 03-04-2021 | Match details |
| 10 | Gavin Coombes | Toulouse | 03-04-2021 | Match details |
| 8 | Joey Carbery | Toulouse | 03-04-2021 | Match details |
| 6 | JJ Hanrahan | Harlequins | 13-12-2020 | Match details |
| 5 | Gavin Coombes | Harlequins | 13-12-2020 | Match details |
| 5 | Michael Haley | Clermont Auvergne | 19-12-2020 | Match details |
| 5 | CJ Stander | Clermont Auvergne | 19-12-2020 | Match details |
| 5 | Kevin O'Byrne | Clermont Auvergne | 19-12-2020 | Match details |
| 3 | Ben Healy | Harlequins | 13-12-2020 | Match details |
| 3 | JJ Hanrahan | Toulouse | 03-04-2021 | Match details |
| 2 | Craig Casey | Toulouse | 03-04-2021 | Match details |
