| Penalties | Players | Club | VS Club | Date | |
|---|---|---|---|---|---|
| 3 |  Immanuel Libbok | Western Stormers | Edinburgh Rugby | 04-06-2022 | Match details |
| 2 | Curwin Bosch | Sharks | Bulls | 04-06-2022 | Match details |
| 2 | Chris Smith | Bulls | Sharks | 04-06-2022 | Match details |
| 2 | Chris Smith | Bulls | Western Stormers | 18-06-2022 | Match details |
| 1 |  John Cooney | Ulster | Munster | 03-06-2022 | Match details |
| 1 |  Emiliano Boffelli | Edinburgh Rugby | Western Stormers | 04-06-2022 | Match details |
| 1 | Chris Smith | Bulls | Leinster | 10-06-2022 | Match details |
| 1 | Morne Steyn | Bulls | Leinster | 10-06-2022 | Match details |
| 1 | John Cooney | Ulster | Western Stormers | 11-06-2022 | Match details |
| 1 | Immanuel Libbok | Western Stormers | Bulls | 18-06-2022 | Match details |
