| A(D) | Club | VS | MD | |
|---|---|---|---|---|
| 24(115) | Montpellier | Leinster | 16-Jan-2022 | Match Details |
| 25(290) | Stade Francais | Bristol Bears | 15-Jan-2022 | Match Details |
| 25(70) | Cardiff Blues | Harlequins | 18-Dec-2021 | Match Details |
| 25(113) | Leicester Tigers | Clermont Auvergne | 10-Apr-2022 | Match Details |
| 25(144) | Bath | Leinster | 22-Jan-2022 | Match Details |
| 26(198) | Begles-Bordeaux | Scarlets | 16-Jan-2022 | Match Details |
| 26(274) | Sale Sharks | Bristol Bears | 09-Apr-2022 | Match Details |
| 26(356) | Harlequins | Castres | 21-Jan-2022 | Match Details |
| 26(17) | Glasgow Warriors | Exeter Chiefs | 15-Jan-2022 | Match Details |
| 26(55) | Northampton Saints | Racing CF | 23-Jan-2022 | Match Details |
| 26(140) | Ulster | Clermont Auvergne | 22-Jan-2022 | Match Details |
| 26(157) | Connacht | Stade Francais | 23-Jan-2022 | Match Details |
| 26(165) | Leinster | Montpellier | 16-Dec-2021 | Match Details |
| 27(239) | London Wasps | Toulouse | 15-Jan-2022 | Match Details |
| 27(245) | Ospreys | Racing CF | 15-Jan-2022 | Match Details |
| 27(276) | Toulouse | Cardiff Blues | 11-Dec-2021 | Match Details |
| 27(312) | Bristol Bears | Sale Sharks | 09-Apr-2022 | Match Details |
| 27(107) | Clermont Auvergne | Ulster | 11-Dec-2021 | Match Details |
| 28(203) | Exeter Chiefs | Montpellier | 23-Jan-2022 | Match Details |
| 28(262) | Munster | Castres | 18-Dec-2021 | Match Details |
| 28(340) | Racing CF | La Rochelle | 15-May-2022 | Match Details |
| 28(48) | La Rochelle | Leinster | 28-May-2022 | Match Details |
| 29(219) | Castres | Munster | 18-Dec-2021 | Match Details |
| 29(11) | Scarlets | Bristol Bears | 22-Jan-2022 | Match Details |
MD = Match date,
A(D) = Age(days).