| A(D) | Club | VS | MD | |
|---|---|---|---|---|
| 23(153) | Zebre | Leinster | 09-Oct-2021 | Match Details |
| 24(200) | Lions | Zebre | 24-Sep-2021 | Match Details |
| 25(294) | Western Stormers | Benetton Treviso | 25-Sep-2021 | Match Details |
| 25(4) | Connacht | Ospreys | 26-Nov-2021 | Match Details |
| 25(68) | Edinburgh Rugby | Gwent Dragons | 27-Nov-2021 | Match Details |
| 26(206) | Benetton Treviso | Ospreys | 16-Oct-2021 | Match Details |
| 26(242) | Munster | Scarlets | 10-Oct-2021 | Match Details |
| 26(244) | Ospreys | Cardiff Blues | 02-Oct-2021 | Match Details |
| 26(248) | Sharks | Glasgow Warriors | 02-Oct-2021 | Match Details |
| 26(335) | Ulster | Glasgow Warriors | 24-Sep-2021 | Match Details |
| 26(108) | Gwent Dragons | Cardiff Blues | 23-Oct-2021 | Match Details |
| 27(234) | Glasgow Warriors | Benetton Treviso | 27-Nov-2021 | Match Details |
| 27(245) | Leinster | Gwent Dragons | 03-Oct-2021 | Match Details |
| 27(57) | Bulls | Edinburgh Rugby | 16-Oct-2021 | Match Details |
| 28(226) | Scarlets | Lions | 01-Oct-2021 | Match Details |
| 28(96) | Cardiff Blues | Sharks | 16-Oct-2021 | Match Details |
MD = Match date,
A(D) = Age(days).